RasGrf1: genomic imprinting, VSELs, and aging
نویسندگان
چکیده
منابع مشابه
RasGrf1: genomic imprinting, VSELs, and aging
Increase in life span in RasGrf1-deficient mice revealed that RasGrf1 deficiency promotes longevity. Interestingly, RasGrf1 is one of parentally imprinted genes transcribed from paternally-derived chromosome. Erasure of its imprinting results in RasGrf1 downregulation and has been demonstrated in a population of pluripotent adult tissues-derived very small embryonic like stem cells (VSELs), ste...
متن کاملRasGrf1 and Aging
several interesting and surprising findings [1]. The most intriguing finding was that the complete elimination of normal RasGrf1 increased both average and maximal longevity independent of a role in cancer. We found this to be surprising because RasGrf1, a Ca 2+ /calmodulin-dependent Ras-guanine-nucleotide-releasing factor, would be expected to have a role in normal physiology [2]. The effect o...
متن کاملGenomic Imprinting
BACKGROUND Genomic imprinting is the inheritance out of Mendelian borders. Many of inherited diseases and human development violates Mendelian law of inheritance, this way of inheriting is studied by epigenetics. AIM The aim of this review is to analyze current opinions and options regarding to this way of inheriting. RESULTS Epigenetics shows that gene expression undergoes changes more com...
متن کاملRasGrf1 deficiency delays aging in mice
RasGRF1 is a Ras-guanine nucleotide exchange factor implicated in a variety of physiological processes including learning and memory and glucose homeostasis. To determine the role of RASGRF1 in aging, lifespan and metabolic parameters were analyzed in aged RasGrf1(-/-) mice. We observed that mice deficient for RasGrf1(-/-) display an increase in average and most importantly, in maximal lifespan...
متن کاملGenomic imprinting
Genomic imprinting is the epigenetic phenomenon by which certain genes are expressed in a parent-of-origin-specific manner. If the allele inherited from the father is imprinted, it is thereby silenced, and only the allele from the mother is expressed. If the allele from the mother is imprinted, then only the allele from the father is expressed. Forms of genomic imprinting have been demonstrated...
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ژورنال
عنوان ژورنال: Aging
سال: 2011
ISSN: 1945-4589
DOI: 10.18632/aging.100354